Plasma galectin-3 (Gal-3) is elevated in, and drives, diverse inflammatory disorders, including cardiovascular diseases, diabetes, and cancer where it promotes tumor growth and metastasis. This study showed for the first time that two apheresis systems performing a procedure where blood is removed, separated, filtered and returned, were able to remove a modest amount of galectin-3.

Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. The resistance was completely transferable to WT recipient mice through SR/CR splenocytes, bone marrow cells, or enriched peritoneal macrophages, either for prevention against subsequent cancer challenges or eradication of established malignancy at distant sites.